Bundesliga
Regular Season (15)
RB Leipzig
MATCH FINISHED
21 Dec
1
:
3
Bayer 04
1
2.08
X
4.00
2
3.30
U 2.5
2.75
O 2.5
1.48
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X 3.35
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2.5
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RB Leipzig vs Bayer 04: prediction & betting odds 21 Dec 2025

The Matchday 15 Bundesliga fixture between Leipzig and Bayer Leverkusen will take place on December 20 at the Red Bull Arena. Leipzig vs. Bayer: prediction and betting odds, statistics.

Leipzig

Ole Werner's side were beaten 3-1 away by Union in the last round. It was Leipzig's third defeat in the current Bundesliga season, and in each of those losses the club conceded at least three goals. At home, however, the team remain perfect this season — the only side in the Bundesliga with six home wins. Leipzig sit second in the table with 29 points.

  • The club have won by at least a two-goal margin in 5 of their last 6 home Bundesliga matches.
  • The team have scored at least twice in each of their previous eight home league matches.
  • Both teams have scored in 7 of Leipzig's last 10 home Bundesliga fixtures.

Predicted lineup for Leipzig (4-3-3)

Peter Gulacsi – David Raum, Castello Lukeba, Willi Orban, Kosta Nedelkovic – Xaver Schlager, Christoph Baumgartner, Nicolas Seiwald – Johan Bakayoko, Konrad Laimer, Yann Diomande.

Defender Bote Baku, midfielder Assan Ouédraogo and forward Antonio Nusa will miss out through injury. Midfielder Amadou Haidara and forward Yann Diomande are away on international duty at the Africa Cup of Nations.

Bayer Leverkusen

Kasper Hjulmand's side beat Cologne 2-0 at home in the last round. Bayer returned to winning ways after two consecutive league defeats and recorded their fourth clean sheet of the season. Leverkusen have 26 points and remain fourth in the table. The team have scored 30 goals this campaign, second only to Bayern Munich (51).

  • The club are unbeaten in 38 of their last 40 away league matches (26 wins, 12 draws).
  • Both teams have scored in 7 of the side's previous 9 away Bundesliga fixtures.
  • Leverkusen have scored at least two goals in 6 of their last 8 league away games.

Predicted lineup for Bayer Leverkusen (3-4-3)

Lukáš Hrádecký – Jerrell Quansah, Robert Andrich, Edmond Tapsoba – Aleix Garcia, Ibrahim Maza, Jonas Hofmann, Arreola – Malik Tillman, Kristijan Koffan, Ernest Poku.

Midfielder Exequiel Palacios is out injured. Defender Jerrell Quansah is suspended. Edmond Tapsoba, Ibrahim Maza and Eliesse Ben Seghir are on international duty at the Africa Cup of Nations.

Referee

Benjamin Brand (Germany)

Matches – 7 (Bundesliga, 2025/26);

Yellow cards shown (including second yellows) – 23;

Average yellow cards per match – 3.3;

Red cards shown – 0;

Average fouls per match – 19;

Penalties – 29%.

Leipzig vs. Bayer Leverkusen: Match Prediction

Leipzig's home form is impressive: they have won all six of their domestic home matches this season. Werner's side have been ruthless in attack, scoring at least twice in each of their previous eight home Bundesliga fixtures, including three goals against Bayern and six in their last home league game against Eintracht.

Leverkusen's away results have dipped recently, largely due to a drop in defensive standards. In their last eight Bundesliga away matches the visitors have failed to keep a clean sheet and conceded at least two goals in six of those games. This season Leverkusen have conceded twice away to Augsburg and three times to Mainz, for example.

I expect Leipzig to be productive in this fixture. My prediction: Leipzig individual total over 1.5

* The starting lineup listed for each team reflects the side that started their previous match in this competition.

RB Leipzig vs Bayer 04 Odds

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OVER/UNDER
BTTS
TOTAL HOME GOALS
TOTAL AWAY GOALS
Bookie1X2

Bundesliga: previous matches of the tournament

RB Leipzig
13.12.25
Union Berlin
RB Leipzig
L
07.12.25
RB Leipzig
Eintracht Frankfurt
W
29.11.25
Borussia Mönchengladbach
RB Leipzig
D
24.11.25
RB Leipzig
Werder Bremen
W
09.11.25
Hoffenheim
RB Leipzig
L
02.11.25
RB Leipzig
Stuttgart
W
26.10.25
Augsburg
RB Leipzig
W
19.10.25
RB Leipzig
Hamburger
W
04.10.25
Borussia Dortmund
RB Leipzig
D
27.09.25
Wolfsburg
RB Leipzig
W
21.09.25
RB Leipzig
Köln
W
13.09.25
Mainz 05
RB Leipzig
W
30.08.25
RB Leipzig
Heidenheim
W
23.08.25
Bayern Munich
RB Leipzig
L
More matches
Bayer 04
14.12.25
Bayer 04
Köln
W
07.12.25
Augsburg
Bayer 04
L
30.11.25
Bayer 04
Borussia Dortmund
L
23.11.25
Wolfsburg
Bayer 04
W
09.11.25
Bayer 04
Heidenheim
W
02.11.25
Bayern Munich
Bayer 04
L
27.10.25
Bayer 04
Freiburg
W
19.10.25
Mainz 05
Bayer 04
W
04.10.25
Bayer 04
Union Berlin
W
27.09.25
St. Pauli
Bayer 04
W
22.09.25
Bayer 04
Borussia Mönchengladbach
D
13.09.25
Bayer 04
Eintracht Frankfurt
W
30.08.25
Werder Bremen
Bayer 04
D
23.08.25
Bayer 04
Hoffenheim
L
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H2H: RB Leipzig — Bayer 04

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01.09.24
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Bundesliga 2023-2024
21.01.24
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19.08.23
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Bundesliga 2022-2023
24.04.23
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30.10.22
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Bundesliga 2021-2022
18.04.22
Bayer 04
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29.11.21
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Bundesliga 2020-2021
31.01.21
RB Leipzig
Bayer 04
26.09.20
Bayer 04
RB Leipzig
Bundesliga 2019-2020
02.03.20
RB Leipzig
Bayer 04
05.10.19
Bayer 04
RB Leipzig
Bundesliga 2018-2019
07.04.19
Bayer 04
RB Leipzig
12.11.18
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Bayer 04
Bundesliga 2017-2018
10.04.18
RB Leipzig
Bayer 04
19.11.17
Bayer 04
RB Leipzig
Bundesliga 2016-2017
08.04.17
RB Leipzig
Bayer 04
19.11.16
Bayer 04
RB Leipzig
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Team lineups

RB Leipzig

Ole Werner
coach
Player Matches Goals
Line-up
Péter Gulácsi
gk. 0 0
Castello Junior Lukeba
df. 0 0
David Raum
df. 0 0
Kosta Nedeljković
df. 0 0
Vilmos Tamás Orbán
df. 0 0
Christoph Baumgartner
mf. 0 0
Nicolas Seiwald
mf. 0 0
Xaver Schlager
mf. 0 0
Conrad Harder
fw. 0 0
Rômulo José Cardoso da Cruz
fw. 0 0
Tidiam Diadie Stephan Gomis
fw. 0 0
Substitutes
Maarten Vandevoordt
gk. 0 0
El Chadaille Bitshiabu
df. 0 0
Lukas Manuel Klostermann
df. 0 0
Max Finkgräfe
df. 0 0
Andrija Maksimović
mf. 0 0
Benno Valentin Kilan Kaltefleiter
mf. 0 0
Bote Ridle Nzuzi Baku
mf. 0 0
Samba Konaté
fw. 0 0
Timo Werner
fw. 0 0
Bayer 04

Kasper Hjulmand
coach
Player Matches Goals
Line-up
Mark Flekken
gk. 0 0
Jeanuël Merick Belocian
df. 0 0
Loïc Séri Badé
df. 0 0
Robert Andrich
df. 0 0
Aleix García Serrano
mf. 0 0
Arthur
mf. 0 0
Jonas Hofmann
mf. 0 0
Malik Leon Tillman
mf. 0 0
Martin Albert Frédéric Terrier
mf. 0 0
Nathan Adewale Temitayo Tella
mf. 0 0
Patrik Schick
fw. 0 0
Substitutes
Janis Jonathan Blaswich
gk. 0 0
Niklas Uwe Bernd Lomb
gk. 0 0
Axel Tape-Kobrissa
df. 0 0
Lucas Vázquez Iglesias
df. 0 0
Ignacio Ezequiel Agustín Fernández Carballo
mf. 0 0
Jeremiah Dennit Mensah
mf. 0 0
Montrell Amare Culbreath
mf. 0 0
Alejo Sarco
fw. 0 0
Christian Michel Kofane
fw. 0 0
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